Article: Copper-Catalyzed Arylation of Heterocycle C-H Bonds (Orgchem)

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Copper-Catalyzed Arylation of Heterocycle C-H Bonds

Hien-Quang Do and Olafs Daugulis
J. Am. Chem. Soc., 129 (41), 12404 -12405, 2007

Abstract:
A new method for the direct, copper-catalyzed arylation of heterocycle C-H bonds by aryl halides has been developed. In addition to electron-rich five-membered heterocycles, electron-poor pyridine oxides can also be arylated. The best results are obtained by using a combination of lithium tert-butoxide base, aryl iodide coupling partner, and copper iodide catalyst.

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